I'm a San Francisco based scientist. Currently at Arsenal I work on engineering T cells to make potent cancer therapeutics. Previously, I was at Andes Bio engineering microbes to combat climate change.
I completed my doctoral work at the University of California, San Francisco where I engineered CRISPR-Cas3 systems as new genome engineering tools and discovered mechanisms of microbial immunity with Joe Bondy-Denomy.
University of California San Francisco• 2016 - 2020
Our team developed and demonstrated the utility of CRISPR-Cas3 for the targeted removal of large segments of DNA, from 20kb to 400kb at a time- in Pseudomonas aeruginosa, Pseudomonas syringae, Escherichia coli, and Klebsiella pneumoniae.
You can read our manuscript from 2020 at
Nature Methods.
University of California San Francisco• 2016 - 2021
We took a deep dive into the biology of the CRISPR-Cas3 system we used to design our genome editing tool. In this work, we describe the evolutionary interplay between bacteria and phage and report on the discovery of a suite of new Cas3 anti-CRISPRs.
Our manuscript is available from Nucleic Acids Research
University of California San Francisco• 2016 - 2021
I was a supporting scientist on work involving Cas12 anti-CRISPR discovery and the jumbo phage PhiKZ, which encodes a nucleus-like compartment to shelter its DNA during replication.
Papers describing this work are available from Science and Nature